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. Author manuscript; available in PMC: 2019 May 22.
Published in final edited form as: J Pharmacokinet Pharmacodyn. 2018 Jan 6;45(1):159–180. doi: 10.1007/s10928-017-9567-4

Fig. 8.

Fig. 8

A minimal intervention analysis of the Boolean network of signaling pathways in multiple myeloma [23]. Network perturbations that result in apoptosis turning ON and growth turning OFF were identified for up to (a) two-node and (b) three-node interventions. The number of times a node was perturbed relative to the total number of intervention sets (52 and 427 intervention sets for two-node and three-node perturbations) is shown on the y-axis, and the x-axis depicts the intervention targets. Red bars indicate the activation of a node (ON), and blue bars indicate the inactivation of a node (OFF).