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. 2019 Apr 12;9(8):2209–2223. doi: 10.7150/thno.30726

Figure 6.

Figure 6

LL-37 is required for the activation of Wnt/β-catenin signaling. (A) Immunohistochemical analysis of the expression of unphosphorylated β-catenin, PCNA, and Ki67 in C57BL/6 mice inoculated with 2×105 LLC cells with indicated treatments. Scale bar, 50 μm. (B) Immunoblotting analysis of unphosphorylated β-catenin, total β-catenin, phosphorylated Gsk3β, pan Gsk3β, phosphorylated Akt, pan Akt, cyclin D1, c-myc, TTP, and β-actin in tumor lysates from C57BL/6 mice inoculated with 2×105 LLC cells with indicated treatments. (C)(D)(E)(F) qRT-PCR analysis of the relative mRNA levels of Axin2 (C), LEF1 (D), TCF1 (E), and TTP (F) in tumor lysates from C57BL/6 mice inoculated with 2×105 LLC cells with indicated treatments.