Figure 1.

P4HB expression increases with cancer grade and is associated with reduced survival. Significant differences in P4HB expression were observed using Kruskal-Wallis (KW) statistics across glioma grade and normal tissue. P4HB had significantly increased expression in patients with GBM compared to patients with LGG in the Rembrandt (a), Gravendeel (b), and TCGA (c) datasets. Patients with increased P4HB expression (regardless of grade) exhibited reduced survivability in three glioma datasets (d-f). Populations were stratified using median P4HB expression per dataset.