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. 2019 Apr 12;9(8):2282–2298. doi: 10.7150/thno.30621

Figure 4.

Figure 4

BAP2 analogs inhibit GBM cell growth and prevent maintenance of stemness properties. (a) Treatment with BAP1-6 inhibited colony formation. (b) A significant correlation exists between PDI inhibition and compound cytotoxicity. (c) BAP2 induced cell death in patient-derived GBM cell lines. (d) PDI knockdown inhibited U87MG sphere formation. Five representative images were taken for each condition. (e) BAP analogs inhibited U87MG sphere formation. Five representative images are shown for each condition. (f) BAP2 impaired sphere formation in four patient-derived GBM cell lines, whereas BAP30 showed no significant inhibition. (g) BAP2 (10 μM), but not BAP30 (10 μM), reduced CD133 population in human GBM cells. Cells were treated with BAP2 or BAP30 for 72 h. (h) BAP2 downregulated Sox2 expression, as assessed by Western blot analysis. Means ± SEM were calculated from three experiments. Scale bars represent 200 μm. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.