Figure 6.

BAP2 affects DNA replication and other signaling pathways as assessed by Bru-seq. Functional terms represented by genes upregulated and downregulated at least eight-fold (log2(fold change) ≥ 3) by BAP2 (a) or siPDI (log2(fold change) ≥ 1) (b). Pathways highlighted in pink represent gene sets that were identified over both BAP2 and siPDI treatment. (c) BAP2 treatment enriched for downregulation of E2F targets and DNA replication gene sets. NES: normalized enrichment score. FDR q val: false discovery rate q value. Criteria for GSEA was false discovery rate < 0.05 %. (d) Transcription of 47 of 63 heat shock proteins increased after BAP2 treatment.