Figure 7.

Influence of MMP-2/9 inhibitor APR100 on microvascular network formation. Aligned and randomly organized microvascular networks formed under 1 µM, 5 µM and 10 µM of APR100 after 7 days of EC culture. No APR100 in the control groups. White arrows and asterisks (*) indicate the vessel walls and the structural gaps within microvascular networks, respectively. Both aligned and randomly organized control groups showed intact vessel wall, whereas fewer microvessels and large structural gaps appeared within branches of microvascular networks in MMP-inhibited samples, especially those with higher APR100 concentration.