TABLE 2: Average EC50 Values by Flavor Categories.
Compiled EC50 values (% volume of e-liquid) by flavor categories. “Flavorless” e-liquids include Flavorless (Vapor Emporium), Clear (Mister-E-Liquid), and Flavorless (Vape Dudes). “Coffee” e-liquids include Irish Latte (Lotus), G.T.F.O. (Mister-E-Liquid), and Irish Coffee (Vape Dudes). “Fruity” e-liquids include Sweet Melon (Lotus), Watermelon (Mister-E-Liquid), Watermelon Drip (Vape Dudes), Mango Blast (Lotus), XXX Berry (Lotus), Heartbreaker (Mister-E-Liquid), and Possum Sauce (Vape Dudes). “Menthol” e-liquids include Menthol (Lotus), Mister E’s Menthol (Mister-E-Liquid), and ICE ICE (Vape Dudes). “Cinnamon” e-liquids includes Fireball (Lotus), Napalm (Mister-E-Liquid), and Cinn Candy (Vape Dudes). * denotes significant difference when compared to the flavorless category within a cell line (p <0.05). † denotes significant difference when compared to same e-liquid treatment in other cell line (p <0.05).
| Cell Line | Nicotine | Flavorless | Fruity | Coffee | Menthol | Cinnamon |
|---|---|---|---|---|---|---|
| MG-63 | − | 4.90±0.13 | *2.64±0.05 | 4.09±0.22 | *1.92±0.04 | *1.40±0.09 |
| + | 4.80±0.21 | *2.45±0.06 | *3.29±0.29 | *1.68±0.05 | *1.02±0.20 | |
| Saos-2 | − | †3.08±0.06 | 2.36±0.06 | 2.60±0.05 | *2.14±0.03 | †*<0.004 |
| + | †2.99±0.06 | 2.23±0.10 | *2.13±0.14 | *1.94±0.09 | †*<0.004 |