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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):1253–1261. doi: 10.1161/ATVBAHA.119.312626

Figure 4: Comparison of variant level-effects with arterial stiffness index and with coronary artery disease shows inconsistency.

Figure 4:

Variant-level effect estimates (from CARDIOGRAMplusC4D) from variants at 77 independent known CAD loci, were compared to their ASI associations. Highlighted are 5 out of the 77 variants with at least suggestive significance with ASI (P<0.005), showing that ASI-raising alleles have inconsistent effects on CAD risk. The variant-level summary statistics for these 77 variants across are detailed in Supplementary Tables XII-XIII.

ASI = arterial stiffness index, CAD = coronary artery disease