Table 1.

Plasma lipid, glucose, insulin, AST, and bile acid levels of female LDLRKO and FMO3KO/LDLRKO mice maintained on a Western diet for 3 months

Genotype (n)	LDLRKO (27)	FMO3KO/LDLRKO (16)	p-value
Triglyceride (mg/dL)	233 ± 21	197 ± 20	0.26
Total Cholesterol (mg/dL)	1504 ± 39	1292 ± 45	0.002
HDL Cholesterol (mg/dL)	85 ± 3	85 ± 3	0.97
VLDL/IDL/LDL Cholesterol (mg/dL)	1419 ± 39	1206 ± 44	0.0013
Glucose (mg/dL)	229 ± 9	201 ± 9	0.045
Insulin (pg/ml)	605 ± 65	506 ± 37	0.19*
HOMA-IR	10.7 ± 1.2	7.8 ± 0.6	0.03*
AST (U/L)	179 ± 14	170 ± 44	0.83
Bile acids (μM)	11.4 ± 0.7	16.1 ± 5	0.25

Plasma lipids, glucose, and insulin data were collected from 2 independent cohorts of mice. Mice were fasted for 4 hours before blood collection. Values shown are mean ± standard error of each group. Sample sizes for AST and bile acids were 17 and 9 for LDLRKO and FMO3KO/LDLRKO, respectively. Student’s t test was used for data analysis unless noted otherwise.

^*: Unpaired t test with Welch’s correction was used for data analysis due to unequal variances of the two groups.