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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: J Pharmacokinet Pharmacodyn. 2019 Apr 26;46(3):305–318. doi: 10.1007/s10928-019-09639-2

Figure-1:

Figure-1:

Structure of the whole-body platform PBPK model. All organs are represented by a rectangular compartment, and connected in an anatomical manner with blood flow (solid arrows) and lymphatic flow (dashed arrows). Arrows represent the direction of the flow. Each tissue within this model, except blood and lymph node, is divided into sub-compartments, as shown in Figure-2.