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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: J Pharmacokinet Pharmacodyn. 2019 Apr 26;46(3):305–318. doi: 10.1007/s10928-019-09639-2

Figure-3:

Figure-3:

PBPK model predicted vs. observed plasma PK profiles of different-size proteins. The solid lines represent model predictions, and solid symbols represent pool observed data from one or more studies. The dataset include: nanobody (13 kDa, n=3), scFv (27 kDa, n=13), diabody (50kDa, n=2), Fab (50kDa, n=6), scFv2 (55 kDa, n=2), minibody (80 kDa, n=3), F(ab)2 (100 kDa, n=6), scFv-Fc (105 kDa, n=2), and IgG in FcRn KO mice (150 kDa, n=1).