Table-2.
PBPK model parameters that do not change based on protein size.
| Parameter | Description | value |
|---|---|---|
| rL (nm) | Large pore radius | 22.85 [14] |
| rS (nm) | Small pore radius | 4.44 [14] |
| αL | Fractional hydraulic conductance of large pores | 0.042 [3,18] |
| αS | Fractional hydraulic conductance of small pores | 0.958 [3,18] |
| Clup (L/hr/L) | Pinocytosis rate of vascular endothelial cells | 0.55 [5] |
| GFR (mL/min) | Glomerular filtration rate in mouse | 0.278 [26] |
| kdeg (1/hr) | First order lysosomal degradation rate | 32.2 [5] |
| σi | Lymphatic reflection coefficient | 0.2 [5] |