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. Author manuscript; available in PMC: 2019 Nov 20.
Published in final edited form as: Nat Immunol. 2019 May 20;20(6):701–710. doi: 10.1038/s41590-019-0397-y

Figure 3: Type I IFN and CD8 T cells play critical roles in inducing infection-associated cachexia.

Figure 3:

a) Serum cytokine concentration of LCMV-infected wild-type mice (n=4). Data are representative of a single experiment. b) Body weight of LCMV-infected mice, either genetically ablated from IFNγ or TNF (n=4), or treated with anti-IFNγ or anti-TNF depleting antibodies (n=5), or a combination of both (n=9). Data are representative of a single experiment for genetic knockouts, two independent experiments for single antibody treatment, and pooled data from two independent experiments for the double depletion of IFNγ and TNF. c) Mice treated with anti-IL-6 depleting antibodies (n=5). d) Ifnar1−/− mice (n=4) (p-values: ****< 0.0001 two-way ANOVA) e) Mice treated with anti-CD4 depleting antibodies (n=4). f) Cd8−/− mice and mice treated with anti-CD8 depleting antibodies (n=4) (p-values: *0.027, *0.046 two-way ANOVA). c-f) are representative of two independent experiments. Data shows mean ± s.e.m.