Table 2:

Plasma concentrations of the markers by CD phenotype

	COL3A1	COMP	anti-CSF2	ASCA-IgA	ASCA-IgG	OmpC	CBir	ANCA
Group1 (n=40)	1762.53 (634.05,2722.56)	88.67 (58.76,136.38)	0.88 (0.38,2.85)	8.31 (3.08,14.99)	20.79 (8.22,41.03)	5.98 (5.07,10.16)	18.2 (7.53,43.27)	15.16 (9.7,22.13)
Group2 (n=33)	1852.75 (1325.46,3043.74)	54.5 (36.57,82.9)	3.06 (1.62,6.86)	22.12 (9.03,44.77)	34.04 (21.2,62.59)	8.63 (5.79,14.7)	43.34 (16.74,110.94)	13.02 (8.75,17.1)
Group3 (n=48)	2293.81 (1436.31,3675.97)	77.88 (59.49,96.05)	2.84 (1.36,7.18)	14.26 (4.78,43.52)	30.59 (7.82,66.64)	10.28 (6.1,14.93)	32.58 (14.29,87.78)	12.87 (8.4,16.54)
Control (n=40)	1739.21 (1032.85,2286.66)	57.93 (44.31,93.3)	0.77 (0.41,2.12)	1.44 (0.3,2.96)	6.02 (2.81,9.35)	5.11 (3.87,6.68)	12.17 (7.99,19.43)	12.64 (8,18.29)
Overall p-value*	0.003	0.003	<.001	<.001	<.001	<.001	<.001	0.34
Pairwise comparisons using Dunn’s test with Bonferroni adjustment
Group.1 vs. Group.2	0.879	0.007	0.012	0.062	0.189	0.660	0.073	-
Group.1 vs. Group.3	0.009	1.000	0.014	0.800	1.000	0.107	0.094	-
Group.1 vs. Control	1.000	0.070	1.000	<.001	<.001	0.409	0.557	-
Group.2 vs. Group.3	0.807	0.065	1.000	1.000	1.000	1.000	1.000	-
Group.2 vs. Control	1.000	1.000	0.052	<.001	<.001	0.004	<.001	-
Group.3 vs. Control	0.012	0.461	0.076	<.001	<.001	<.001	<.001	-

^*The p-values are all from non-parametric tests. Kruskal-Wallis test for difference in median among the patient groups. If the overall p-value is significant, then Dunn’s test is done for pairwise comparisons with Bonferroni multiple adjustment. These are reported in the sub-table below the main results.

OL3A1 = collagen type III alpha 1 chain (pg/mL), COMP = cartilage oligomeric matrix protein (ng/mL), Anti-CSF2 = autoantibodies against colony stimulating factor 2 (ng/mL), ASCA = anti- Socchoromyces cerevisiae antibodies (EU/mL), OmpC = anti-outer membrane protein C precursor (EU/mL), CBir = anti-flagellin (EU/mL), ANCA = perinuclear anti-neutrophil cytoplasmic antibodies