Figure 5:

Aberrant expression of proteins invovled in otolith development in csr and nco. (A) Schematic of anterior macula (AM) tethered to otolith at 27 hpf. (B) In WT, Otoconin-90 (Oc90) is expressed within the mineralized otolith, which is situated atop the otolithic membrane (Otogelin, or Otog), at 27 hpf. Scale bar = 5 μm. (C-D) Oc90 has diffuse expression within the otocyst of csr and nco. In csr and nco, Otog is localized near the apical surface of hair cells. (E-F) Expression showing hair cells in WT and nco larvae at 5dpf. Scale bar = 25 μm. (G) Quantification of hair cell numbers in the posterior and anterior macula of WT and nco (n = 4).