Table I.
Model Variables and Terms Used in Equations
| Variable | Definition | Unit |
|---|---|---|
| TotPcad t | Total Pcad in the tumor | nM |
| TotCD3 p | Total CD3 in the central compartment | nM |
| TotCD3 t | Total CD3 in the tumor | nM |
| Tcellsp | T cells in the central compartment | Cells/L |
| Tcellstm | T cells migrated from plasma to tumor, during 5-day lag time | Cells/L |
| Tcellst | T cells in the tumor | Cells/L |
| Dose | Dose of PF-06671008 | nmols |
| C1 | Concentration of PF-06671008 in central compartment | nM |
| C2 | Concentration of PF-06671008 in the peripheral compartment | nM |
| C3 | Concentration of PF-06671008 in the tumor | nM |
| DCD3p | Dimer of PF-06671008-CD3 in the central compartment | nM |
| DCD3t | Dimer of PF-06671008-CD3 in the tumor | nM |
| DPcadp | Dimer of PF-06671008-Pcad in the central compartment | nM |
| DPcadt | Dimer of PF-06671008-Pcad in the tumor | nM |
| Trimer | Trimer of PF-06771008-CD3-Pcad in the tumor | nM |
| w | Total tumor volume | mm3 |
| M1, M2, M3, M4 | Tumor volume in growth and three transduction compartments | nM |