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. 2019 May 22;9:7677. doi: 10.1038/s41598-019-44181-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Depletion of CD11b^HI/Ly6C+ macrophages reduces IL-1β production in E15 fetal liver. Pregnant mice were injected with nonimmune IgG or anti-GR-1 antibody. At E15, macrophages were isolated from fetal liver (a,b) and fetal lung (c,d) Anti-Gr-1 injection reduced the percentage of CD11b^HI/Ly6C+ macrophages in the E15 fetal liver (a) with a corresponding reduction in IL-1β and IL-6 release following treatment of the total fetal liver cell suspension with LPS (*P < 0.05, n = 3; **P < 0.01, n = 4, ***P < 0.001, n = 4). Anti-Gr-1 injections did not reduce CD11b^HI/Ly6C+ macrophages from fetal lungs or reduce IL-1β or IL-6 production following LPS treatment.