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. 2019 May 22;9:7681. doi: 10.1038/s41598-019-44164-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Depicts the CONSORT flow diagram, the adverse events as well as the reasons for withdrawal. With 19 patients withdrawing from the study, the overall dropout rate was 35.19%, with 7 subjects resigning from the control, and 12 subjects from the test group. Six control subjects missed one follow-up appointment each, but continued to participate in the remaining follow-up examinations afterwards²³.