Table 2.
Results of the statistical evaluation of the primary endpoint with three models showing type 3 test-based p-values (primary and model with additional covariates as well as the model after multiple imputation).
| Effect | Primary model | Model with additional covariates | Multiple imputation model |
|---|---|---|---|
| p1-value | p2-value | p3-value | |
| Type 3 test-based p-values of fixed effects | |||
| Group (intervention SnCl2/AmF/NaF) | *0.0242 | *0.0338 | *0.0259 |
| Time of examination | ** < 0.0001 | ** < 0.0001 | |
| Group*time of examination | 0.5970 | 0.8113 | |
| BEWE at t = 0 | ** < 0.0001 | ** < 0.0001 | ** < 0.0001 |
| pH value | 0.9650 | 0.7470 | 0.8681 |
| Age | 0.2977 | ||
| Gender | *0.0294 | ||
| Saliva flow [ml/min] | 0.7937 | ||
| Hypersensitivity by VAS | 0.3367 | ||