Table 3.

Parameter estimates for fixed effects in the primary and enhanced model.

Effect	Primary model			Model with additional covariates			Multiple imputation model
	Estimates	Standard error	p-value	Estimates	Standard error	p-value	Estimates	Standard error	p-value
Parameter estimates for fixed effects
BEWE at t = 0	0.7740	0.0876	** < 0.0001	0.7563	0.1146	** < 0.0001	0.7897	0.1117	** < 0.0001
pH value	0.0115	0.2607	0.9650	−0.0906	0.2802	0.7470	0.0908	0.5464	0.8681
Age				−0.0378	0.0358	0.2977
Gender Female				1.9508	0.8680	*0.0294
Male				0	.	.
Saliva flow [ml/min]				−0.0348	0.1325	0.7937
Hypersensitivity				0.0884	0.0917	0.3367