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. 2019 May 22;9:7696. doi: 10.1038/s41598-019-42773-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CD271 expression has a strong impact on melanoma transcriptome and has distinct effect in melanocytes. (A) Experimental design of patient-derived transcriptomic profiles of CD271⁺ and CD271⁻ melanoma cells in comparison with profiles of healthy donor melanocytes. All cell populations were sorted by flow cytometry and subjected to transcriptomic profiling. (B) Heat map of gene expression profiles and indication of CD271 status in tumor cells (pink and purple) vs normal melanocytes (grey). Selfrenewal, cell cycle and cell survival pathways are significantly overrepresented with p values below 0.05 in CD271⁺ melanoma-initiating cells vs CD271⁻ cells and normal melanocytes. Principal component analysis (PCA) reveals separation of expression profiles.