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. 2019 May 22;9:7696. doi: 10.1038/s41598-019-42773-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Switch in the neurotrophin pathway depends on the expression of the nerve growth factor receptor (CD271/NGFR/p75NTR). Gene expression levels plotted onto map of the neurotrophin pathway in CD271⁺ melanoma-initiating cells. Two divergent arms of neurotrophin signaling balance between self-renewing, cell survival and cell cycle signals on the one hand, and developmental, differentiation and apoptosis triggers on the other hand.