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. 2019 May 22;9:7728. doi: 10.1038/s41598-019-44050-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Division of OPCs is enhanced in the vicinity of the corpus callosum 7 days following lysolecithin-induced demyelination in pregnant rats. (A–C) are immunofluorescent staining images of PCNA (green) and NG2 (red) in lysolecithin-injected corpora callosa of virgin, pregnant, and postpartum animals respectively. (D) The bar graph shows that there was no significant difference in the cell density of dividing OPCs (NG2⁺/PCNA⁺, arrowheads), non-dividing OPCs (NG2⁺/PCNA⁻, arrows) (E), or the total number of NG2⁺ cells (F) between the three experimental groups (Lyso-Vir: n = 6, Lyso-Preg: n = 5, Lyso-PP: n = 4, p > 0.05). (G) The bar graph shows that focally demyelinated corpus callosa of pregnant animals have a significantly higher percentage of NG2⁺/PCNA⁺ cells when compared to those seen in either virgin or postpartum animals (p < 0.05). (H) The bar graph shows that demyelinated corpus callosa of pregnant animals had a significantly lower percentage of NG2⁺/PCNA⁻ cells compared to those seen in either virgin or postpartum animals (p < 0.05). Data are presented as mean ± SEM. Scale bar = 50 µm.