Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 May 22;9:7728. doi: 10.1038/s41598-019-44050-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Axonal myelination is increased 7 days post-lysolecithin-induced demyelination in the corpus callosum of pregnant rats. (A–C) show representative TEM images of the corpus callosum post-lysolecithin injection. Green arrows indicate unmyelinated axons while yellow arrowheads indicate the myelinated ones. (D) Graph shows comparison of the g-ratio between the three experimental groups. The axons seen in the corpus callosum of pregnant rats had a significantly lower g-ratio when compared to those seen in virgin and postpartum animals (Lyso-Vir: n = 4, Lyso-Preg: n = 4, Lyso-PP: n = 3, p < 0.01). (E) Representative figures of western blot for the different myelin proteins. No significant difference was detected in the expression of S-MAG (F) or L-MAG (G) in demyelinated corpora callosa of the three experimental groups (Lyso-Vir: n = 6, Lyso-Preg: n = 5, Lyso-PP: n = 4, p > 0.05). The expression of both MOG (H) and CNPase (I) were significantly higher in the pregnant rats when compared to those seen in either virgin or postpartum rats (p < 0.05). The expression of the 21.5 kDa MBP isoform (J) was not different between the three experimental groups (p > 0.05). Pregnant rats had a significantly higher expression of 18.5 + 17 kDa isoforms (K) when compared to either virgin or postpartum rats (p < 0.01). The expression of the 14 kDa MBP isoform (L) was significantly increased in pregnant rats when compared to either virgin (p < 0.01) or postpartum (p < 0.05) rats. Results are presented as mean ± SEM. Scale bar = 1 µm.