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. 2019 May 22;9:7728. doi: 10.1038/s41598-019-44050-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of Bic on myelin proteins expression 7 days following lysolecithin-induced demyelination in the corpus callosum using western blot. Administration of Bic significantly reduced the expression levels of L-MAG (A) and S-MAG (B) in lysolecithin-injected corpora callosa when compared to those seen in vehicle treated rats (Lyso-Vehicle: n = 4, Lyso-Bic: n = 5, p < 0.05). Bic administration on the other hand did not affect the expression of MOG (C), CNPase (D), or MBP (E) when compared to vehicle-treated rats (p > 0.05). Results are presented as mean ± SEM.