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. 2019 May 22;9:7715. doi: 10.1038/s41598-019-44156-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Unsupervised hierarchical clustering of intratumoral collagen parameters using Ward algorithms and Euclidian distance; the lowest values for intratumoral collagen parameters refer to mucinous (MUC), papillary (PAP) and medullary (MED) breast carcinomas (light blue); the highest values refer to classical invasive lobular (cILC) and tubular carcinomas (TUB) (light yellow); the intermediary values refer to invasive ductal carcinoma of no special type (IBC-NST), micropapillary (mPAP), metaplastic (METAP) and invasive apocrine (APO) (light orange), being the latter group very heterogeneous. QIR: bSHG collagen quantity; QIT: fSHG collagen quantity; EIR: bSHG collagen uniformity; EIT: fSHG collagen uniformity; OIR: bSHG collagen organization; and OIT: fSHG collagen organization. (B) Minimal Spanning Tree (MST) of the Euclidian matrix with three defined intratumoral collagen parameters. The MSP gives a spatial representation of what is shown in the heatplot. Cases presenting similar collagen parameters are linked by a line. As result, cases belonging to the same group (blue, yellow and orange) are concentrated in three branches of the tree: blue in the superior part, yellow in the middle and right region and orange in the left branch.