. 2019 Apr 26;10(3):1099–1111. doi: 10.1007/s13300-019-0626-2

Table 6.

Multivariate analysis for primary clinical outcome

Variable	Multivariate analysis
	Step 1		Step 2		Step 3		Step 4
	HR (95% CI)	p value	HR (95% CI)	p value	HR (95% CI)	p value	HR (95% CI)	p value
Age (years)	1.03 (1.01–1.05)	0.002	1.02 (0.99–1.04)	0.272	1.00 (0.97–1.04)	0.881	1.00 (0.97–1.04)	0.917
Male	2.02 (1.27–3.21)	0.003	1.65 (0.82–3.32)	0.162	1.31 (0.60–2.90)	0.500	1.35 (0.60–3.01)	0.469
History of coronary artery disease			2.52 (1.33–4.77)	0.005	2.61 (1.25–5.45)	0.011	2.83 (1.34–5.97)	0.006
Hypertension			1.00 (0.54–1.85)	0.998	0.75 (0.37–1.49)	0.410	0.72 (0.36–1.46)	0.362
Current smoker (vs never)			1.25 (0.64–2.47)	0.515	1.61 (0.72–3.61)	0.250	1.65 (0.73–3.74)	0.230
Low-density lipoprotein cholesterol (mg/dl)			1.01 (1.00–1.02)	0.004	1.02 (1.01–1.03)	0.004	1.02 (1.01–1.03)	0.004
High-density lipoprotein cholesterol (mg/dl)			0.98 (0.85–1.00)	0.059	0.99 (0.97–1.02)	0.416	0.99 (0.96–1.01)	0.393
Triglycerides (mg/dl)			1.00 (1.00–1.00)	0.983	1.00 (1.00–1.00)	0.706	1.00 (1.00–1.00)	0.626
Hemoglobin A1c (%)			1.04 (0.83–1.31)	1.044	1.00 (0.75–1.32)	0.988	0.94 (0.70–1.27)	0.701
Body mass index (kg/m²)					0.98 (0.90–1.07)	0.651	0.98 (0.90–1.01)	0.639
Estimated glomerular filtration rate (ml/min/1.73 m²)					0.98 (0.97–1.00)	0.064	0.99 (0.97–1.00)	0.097
Retinopathy							1.56 (0.71–3.40)	0.267
Neuropathy							1.11 (0.53–2.34)	0.775
Nephropathy							2.03 (0.90–4.56)	0.087
Hypoglycemia							0.52 (0.07–3.86)	0.523

Step 1: adjusted for age, sex

Step 2: adjusted for age, sex, history of coronary artery disease, hypertension, current smoker, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, hemoglobin A1c

Step 3: adjusted for age, sex, history of coronary artery disease, hypertension, current smoker, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, hemoglobin A1c, body mass index, estimated glomerular filtration rate