Table 2.
Radiologic features of the hepatocellular adenomas
| Case no. | Size (cm) | US pattern (echogenicity) | Color Doppler flow pattern | CEUS arterial phase filling | CEUS portal phase washout | CEUS late phase washout | MRI non-contrast pattern (T1W intensity–T2W intensity) | MRI contrast pattern (arterial–portal–venous T1 W intensity) | Histological diagnosis |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 6.0 | Hyper | No FS | Centrifugal | No | Yes | NA | NA | I-HCA |
| 2 | 2.5 | Hypo | Intralesional AS and VS | Centripetal | No | No | NA | NA | I-HCA |
| 3 | 1.6 | Hypo | Intralesional AS and VS | Centripetal | No | No | Iso–Hyper | Hyper–Hypo–Hypo | I-HCA |
| 4 | 5.1 | Mixed | Perilesional AS and VS, intralesional VS | Centripetal | No | No | Hypo–Hyper | Hyper–Iso–Iso with inhomogeneous internal area suspected for hemorrhagic necrosis | I-HCA |
| 5 | 2.8 | Iso | Perilesional AS/VS | Centripetal | No | No | Hypo–Hyper | Hyper–Hypo–Iso | I-HCA |
| 6 | 3.2 | Hypo | Perilesional AS/VS | Centrifugal | No | Yes | Hypo–Hyper | Hyper–Hypo–Iso | UNC-HCA |
| 7 | 5.6 | Hyper | Perilesional VS | Centripetal | Yes | Yes | Iso–Hyper | Hyper–Hypo–Hypo | B-HCA |
| 8 | 4.8 | Hypo | Perilesional VS | Centripetal | No | Yes | NA | NA | UNC-HCA |
| 9 | 2.1 | Hypo | No FS | Centripetal | No | No | NA | Hyper–Hyper–Hyper | I-HCA |
| 10 | 4.4 | Hypo | No FS | Centripetal | Yes | Yes | Mixed–Mixed | Hyper–Hyper–Hyper with internal hypointense areas | I-HCA |
| 11 | 4.0 | Hyper | Perilesional AS, intralesional AS | Centripetal | No | No | Hypo–Hyper | Hyper–Iso–Iso | I-HCA |
| 12 | 4.0 | Hyper | No FS | No filling | Yes | Yes | NA | NA | UNC-HCA |
| 13 | 3.0 | Hypo | No FS | Centripetal | No | Yes | Hypo–Hyper | Hyper–Hyper–Hyper | I-HCA |
| 14 | 3.9 | Hypo | Perilesional AS | Centripetal | No | No | NA | NA | UNC-HCA |
| 15 | 7.1 | Hyper | Perilesional AS | Centripetal | Yes | Yes | Hypo–Hyper | Hyper–Iso–Hyper | I-HCA |
| 16 | 5.3 | Hyper | Intralesional AS | Centripetal | Yes | Yes | Hypo–Hyper | Hyper–Hyper–Hyper | I-HCA |
| 17 | 6.0 | Mixed | Perilesional AS | Centripetal | No | No | Hyper–Hyper | Hyper–Hyper–Iso | I-HCA |
| 18 | 6.2 | Iso | Intralesional VS | Centripetal | No | Yes | Hyper–Hyper | Hyper–Hyper–Iso | I-HCA |
| 19 | 2.5 | Hypo | Intralesional AS | Centripetal | No | Yes | Iso–Hyper | Hyper–Iso–Iso | I-HCA |
US ultrasound, CEUS contrast-enhanced ultrasound, MRI magnetic resonance imaging, FS flow signals, NA not available, AS arterial signals, VS venous signals, T1W T1-weighted, T2W T2-weighted, I-HCA inflammatory hepatocellular adenoma, UNC-HCA unclassified hepatocellular adenoma, B-HCA β-catenin-activated hepatocellular adenoma