Table 4. Multivariate Cox analysis for association of β-blockers with CI-AKI.
| Variables | Univariate Cox analysis | Multivariate Cox analysis | |||||
|---|---|---|---|---|---|---|---|
| OR | 95% CI | P value | OR | 95% CI | P value | ||
| B-blockers | 0.241 | 0.149–0.388 | <0.001 | 0.520 | 0.291–0.930 | 0.027 | |
| Age | 4.808 | 2.962–7.805 | <0.001 | 3.609 | 1.994–6.530 | <0.001 | |
| Gender | 1.807 | 1.052–3.106 | 0.032 | ||||
| Weight | 0.963 | 0.942–0.985 | 0.001 | ||||
| SBP | 1.000 | 0.989–1.012 | 0.971 | ||||
| DBP | 0.996 | 0.977–1.016 | 0.720 | ||||
| Egfr <60 | 6.275 | 3.894–10.112 | <0.001 | 3.443 | 1.920–6.173 | <0.001 | |
| Anemia | 1.711 | 1.072–2.731 | 0.024 | ||||
| ACEI/ARB | 0.329 | 0.190–0.572 | <0.001 | ||||
| Emergency PCI | 2.816 | 1.656–4.789 | <0.001 | 2.133 | 1.143–3.981 | 0.017 | |
| Peri-hypotension | 8.159 | 4.838–13.762 | <0.001 | 3.421 | 1.724–6.790 | <0.001 | |
| Peri-IABP | 13.370 | 8.040–22.234 | <0.001 | 4.175 | 2.178–8.003 | <0.001 | |
| DM | 1.426 | 0.840–2.420 | 0.189 | 0.909 | 0.464–1.77 | 0.779 | |
| Lesion | 1.519 | 1.193–1.933 | <0.001 | 1.099 | 0.829–1.457 | 0.514 | |
| LVEF <40% | 3.337 | 1.904–5.848 | <0.001 | 2.017 | 1.010–4.031 | 0.047 | |
| Dose >200 | 0.823 | 0.293–2.310 | 0.711 | 0.684 | 0.208–2.250 | 0.532 | |
CI-AKI, contrast-induced acute kidney injury; SBP, systolic blood pressure; DBP, diastolic blood pressure; eGFR, effective glomerular filtration rate; HCT, hematocrit; IABP, intra-aortic balloon pump; DM, diabetes mellitus; LVEF, left ventricular ejection fraction.