Table 4. The univariate and multivariate analyses of overall survival (Cox proportional hazards model).
| Variables | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | ||
| Age (>70 years) | 1.48 | 0.91–2.43 | 0.11 | 1.11 | 0.64–1.95 | 0.71 | |
| Gender (male) | 0.89 | 0.48–1.86 | 0.74 | − | − | − | |
| CCI (≥2) | 1.2 | 0.71–2.00 | 0.5 | − | − | − | |
| Histological type (SCLC) | 1.08 | 0.66–1.79 | 0.74 | − | − | − | |
| Perioperative chemotherapy (performed) | 0.35 | 0.20–0.60 | <0.01 | 0.29 | 0.16–0.52 | <0.01 | |
| Surgical procedure (sublobar resection) | 1.79 | 0.99–3.25 | 0.06 | 2.11 | 1.03–4.08 | 0.04 | |
| Tumor size (≥3 cm) | 0.87 | 0.53–1.41 | 0.58 | − | − | − | |
| Lymph node metastasis (present) | 2.13 | 1.30–3.48 | <0.01 | 3.34 | 1.88–5.94 | <0.01 | |
| Pleural invasion (present) | 0.96 | 0.59–1.58 | 0.89 | − | − | − | |
| Vascular invasion (present) | 0.82 | 0.48–1.43 | 0.5 | − | − | − | |
| Lymphatic permeation (present) | 1.49 | 0.86–2.57 | 0.14 | 1.33 | 0.72−2.55 | 0.37 | |
SCLC, small cell lung cancer; CCI, Charlson Comorbidity Index; HR, hazard ratio; CI, confidence interval.