Table 1. Cohort by diagnosis.
| Cohort | Overall | A1ATD | COPD | P value |
|---|---|---|---|---|
| Entire cohort | n=385 | n=98 | n=287 | |
| Demographics | ||||
| Recipient male (n, %) | 176 (45.7) | 52 (53.1) | 124 (43.2) | 0.116 |
| Caucasian (n, %) | 378 (98.2) | 98 (100.0) | 280 (97.6) | 0.296 |
| Black (n, %) | 5 (1.3) | 0 (0.0) | 5 (1.7) | − |
| Other (n, %) | 2 (0.5) | 0 (0.0) | 2 (0.7) | − |
| Age | ||||
| Recipient (mean ± SD) | 56.5±7.2 | 51.7±8.0 | 58.1±6.1 | <0.001 |
| Donor (mean ± SD) | 35.9±15.0 | 34.4±14.7 | 36.5±15.1 | 0.225 |
| Pulmonary Status | ||||
| Recipient smoker (n, %) | 196 (50.9) | 47 (48.0) | 149 (51.9) | 0.576 |
| Donor smoker (n, %) | 42 (10.9) | 8 (8.2) | 34 (11.8) | 0.411 |
| Transplant | ||||
| LAS era transplant (n, %) | 129 (33.5) | 20 (20.4) | 109 (38.1) | 0.002 |
| Single lung transplant (n, %) | 286 (74.3) | 55 (56.1) | 231 (80.6) | <0.001 |
| Transplant LOS >14 days (n, %) | 170 (44.2%) | 48 (49.0%) | 122 (42.7) | 0.346 |
| LAS cohort | n=129 | n=20 | n=109 | |
| Demographics | ||||
| Recipient male (n, %) | 60 (46.5) | 10 (50.0) | 50 (45.9) | 0.923 |
| Caucasian (n, %) | 127 (98.4) | 20 (100.0) | 107 (99.0) | 0.830 |
| Black (n, %) | 1 (0.8) | 0 (0.0) | 1 (0.9) | − |
| Other (n, %) | 1 (0.8) | 0 (0.0) | 1 (0.9) | − |
| Age | ||||
| Recipient (mean ± SD) | 59.8±5.3 | 57.9±7.1 | 60.1±4.8 | 0.090 |
| Donor (mean ± SD) | 39.6±15.8 | 42.8±14.0 | 39.1±16.1 | 0.336 |
| Pulmonary Status | ||||
| Recipient smoker (n, %) | 126 (97.7) | 20 (100.0) | 106 (97.2) | >0.999 |
| Donor smoker (n, %) | 42 (32.6) | 8 (40.0) | 34 (31.2) | 0.608 |
| Transplant | ||||
| Single lung transplant (n, %) | 87 (67.4) | 12 (60.0) | 75 (68.8) | 0.608 |
| Lung allocation score (mean ± SD) | 37.8±14.7 | 33.7±2.84 | 38.5±15.8 | 0.189 |
| Longest ischemic time (mins, mean ± SD) | 306±147 | 266±160 | 314±144 | 0.228 |
| Transplant LOS >14 days (n, %) | 63 (48.8) | 13 (65.0) | 50 (45.9) | 0.196 |
“Longest ischemic time” refers to the ischemic time of the second lung implanted during BLTx or to the ischemic time of the only implanted lung in SLTx. A1ATD, alpha-1-antitrypsin deficiency; COPD, chronic obstructive pulmonary disease; LAS, lung allocation score; LOS, length of stay; BLTx, bilateral lung transplant; SLTx, single lung transplant.