ProGRP distribution in patients with different lung tumors in stage I–II, III and IV. *, P>0.05; **, P<0.05; ***, P<0.001. ProGRP, roles of gastrin-releasing peptide. NSCLC, non-small cell lung cancer; SCLC, small cell lung cancer; LCNEC, large cell neuro-endocrine carcinoma; AC, atypical carcinoid; TC, typical carcinoid; ProGRP, roles of gastrin-releasing peptide.