Table S5. Comparison of ProGRP and NSE for pathology and histological pathology.

Tumor markers	Stage I–II				Stage III				Stage IV
	Other lung tumors	NEC	Concordance (%)		Other lung tumorsa/b	NEC	Concordance (%)		Other lung tumorsa/b	NEC	Concordance (%)
ProGRPa			30.1				81.3				84.8
Other lung tumorsb	2,590	16			1,366	50			1,776	51
NEC	260	69			51	283			28	264
ProGRP ≥66 ng/L			53.5				81.5				76.1
Other lung tumors	2,775	24			1,371	53			1,712	44
NEC	75	61			46	280			92	271
ProGRP ≥300 ng/L			45.7				79.4				80.5
Other lung tumors	2,846	58			1,328	81			1,792	83
NEC	4	27			14	229			12	232

^a, ProGRP criteria in stage I–II, III and IV are 54, 64, 99 ng/L, respectively; ^b, other lung tumors: NSCLC and pulmonary carcinoid tumor. ProGRP, roles of gastrin-releasing peptide; NSE, neuron-specific enolase; NEC, neuro-endocrine carcinoma; NSCLC, non-small cell lung cancer.