Table 1. Patient demographics and clinical characteristics (clinical stage and overall enrolled population).
| Parameters | Stage IIIA (n=12) | Stage IIIB (n=9) | Stage IV (n=124) | Overall population (N=145) |
|---|---|---|---|---|
| Age, mean (SD), year | 64.6 (8.6) | 68.1 (9.7) | 63.4 (9.7) | 63.8 (9.6) |
| Male, n (%) | 8 (66.7) | 7 (77.8) | 78 (62.9) | 93 (64.1) |
| Race, n (%) | ||||
| Caucasian | 11 (91.7) | 9 (100.0) | 110 (88.7) | 130 (89.7) |
| Asian | 0 (0.0) | 0 (0.0) | 1 (0.8) | 1 (0.7) |
| Other | 1 (8.3) | 0 (0.0) | 13 (10.5) | 14 (9.7) |
| WHO performance status, n (%) | ||||
| 0 | 5 (41.7) | 3 (33.3) | 42 (33.9) | 50 (34.5) |
| 1 | 4 (33.3) | 2 (22.2) | 50 (40.3) | 56 (38.6) |
| 2 | 3 (25.0) | 3 (33.3) | 25 (20.2) | 31 (21.4) |
| 3 | 0 (0.0) | 1 (11.1) | 5 (4.0) | 6 (4.1) |
| 4 | 0 (0.0) | 0 (0.0) | 2 (1.6) | 2 (1.4) |
| Smoking status, n (%) | ||||
| Never smokera | 1 (8.3) | 1 (11.1) | 23 (18.5) | 25 (17.2) |
| Light smokerb | 1 (8.3) | 0 (0.0) | 0 (0.0) | 1 (0.7) |
| Former smoker (≤15 years) | 1 (8.3) | 3 (33.3) | 29 (23.4) | 33 (22.8) |
| Former smoker (>15 years) | 7 (58.3) | 3 (33.3) | 34 (27.4) | 44 (30.3) |
| Current smoker | 2 (16.7) | 2 (22.2) | 38 (30.6) | 42 (29.0) |
| Pack-years, medianc | 45 | 40 | 37 | 40 |
| Method of diagnosis, n (%) | ||||
| Histology | 8 (66.7) | 7 (77.8) | 110 (88.7) | 125 (86.2) |
| Cytology | 4 (33.3) | 2 (22.2) | 14 (11.3) | 20 (13.8) |
| Histological subtype, n (%) | ||||
| Adenocarcinoma | 5 (41.7) | 5 (55.6) | 105 (84.7) | 115 (79.3) |
| Non-adenocarcinoma | 4 (33.3) | 4 (44.4) | 18 (14.5) | 26 (17.9) |
| Squamous cell carcinoma | 3 (25.0) | 2 (22.2) | 6 (4.8) | 11 (7.6) |
| Other | 3 (25.0) | 0 (0.0) | 1 (0.8) | 4 (2.8) |
SD, standard deviation; WHO, World Health Organization. a, <100 cigarettes in their lifespan; b, <15 pack-years or <5 cigarettes per day; c, pack-years: (number of cigarettes smoked per day × number of years smoked)/20.