Table 1. Characteristics of included studies.
| Study | No. of participants | Inclusion criteria | Interventional algorithm | Control group transfusion management | Type of study |
|---|---|---|---|---|---|
| Ak 2009 | 224 | Elective first-time CABG, with CPB | Fully TEG-based algorithm | Clinical judgement and SLTs | RCT |
| Anderson 2006 | 990 | All types of cardiac surgery requiring CPB | Fully ROTEM-based algorithm | Clinical judgement and SLTs | RC |
| Avidan 2004 | 102 | Elective first-time CABG, with CPB | Partly TEG-based algorithm, included the Hepcon and PFA-100 platelet function analyser | SLTs | RCT |
| Fassl 2013 | 62 | Proximal aortic surgery with induced HCA, requiring CPB | Fully ROTEM-based algorithm | Clinical judgement and SLTs | MCC |
| Girdauskas 2010 | 56 | High risk aortic surgery including urgent and emergency surgery with HCA, requiring CPB | Fully ROTEM-based algorithm | Clinical judgement and SLTs | RCT |
| Görlinger 2011 | 3,865 | All types of cardiac surgery requiring CPB | Fully ROTEM-based algorithm | Clinical judgement and SLTs | RC |
| Karkouti 2016 | 7,402 | All types of cardiac surgery requiring CPB | Partly ROTEM-based algorithm | SLTs | RCT |
| Kempfert 2011 | 104 | Adult patients with significant postoperative bleeding (>200 mL/h) following standard elective isolated or combined cardiac surgical procedures | Fully ROTEM-based algorithm | SLTs | RCT |
| Kuiper 2019 | 355 | All types of cardiac surgery requiring CPB | Fully ROTEM-based algorithm | SLTs | PC |
| Kultufan Turan 2006 | 40 | CABG or valve surgery | Fully ROTEM-based algorithm | Clinical judgement and SLTs | RCT |
| Nuttall 2001 | 92 | All types of cardiac surgery requiring CPB, with abnormal microvascular bleeding after CPB | Partly TEG-based algorithm, included point-of-care SLTs | Clinical judgement and SLTs | RCT |
| Paniagua 2011 | 22 | Cardiac surgery requiring CPB, with major postoperative bleeding (>300 mL in the first postoperative hour) | Fully ROTEM-based algorithm | SLTs | RCT |
| Rauter 2007 | 208 | Elective on-pump cardiac surgery | Fully ROTEM-based algorithm | Clinical judgement and SLTs | RCT |
| Royston 2001 | 60 | Surgery requiring CPB, with high risk of requiring hemostatic products (Heart transplantation, revascularization bypass, Ross procedure, multiple valve and revascularization surgery) | Fully TEG-based algorithm | Clinical judgement and SLTs | RCT |
| Shore-Lesserson 1999 | 105 | High risk cardiac procedure with CPB (Single or multiple valve replacement, combined artery bypass plus valvular procedure, cardiac reoperation, thoracic aortic replacement) | Fully TEG-based algorithm | Clinical judgement and SLTs | RCT |
| Spiess 1995 | 1,079 | All types of cardiac surgery requiring CPB | Fully TEG-based algorithm | Clinical judgement | RC |
| St-Onge 2018 | 385 | Cardiac surgery involving aorta with CPB | Fully TEG-based algorithm | Clinical judgement and SLTs | RC |
| Weber 2012 | 100 | Elective complex cardiothoracic surgery with CPB (combined coronary artery bypass graft and valve surgery, double or triple valve procedures, aortic surgery or redo surgery) | Fully ROTEM-based algorithm | Clinical judgement and SLTs | RCT |
| Westbrook 2009 | 69 | All types of cardiac procedures with CPB except lung transplantations | Partly TEG-based algorithm, included Platelet mapping | Clinical judgement and SLTs | RCT |
CPB, cardiopulmonary bypass; CABG, cardiac artery bypass graft; TEG, thromboelastography; ROTEM, rotational thromboelastometry; SLT, standard laboratory tests; RCT, randomized controlled trial; MCC, matched case-control study; RC, retrospective cohort study; PC, prospective cohort study; HCA, hypothermic circulatory arrest.