Table 3.
Top GWAS T2D and associated traits loci co-localising with eQTLs.
| GWAS Catalog | ||||||
|---|---|---|---|---|---|---|
| GWAS gene | SNPS | eQTL SNP | eQTL distance | eQTL FDR | eQTL beta | Probe ID |
| PPP | ||||||
| FREM3 | rs13134327 | rs5015757 | −174187 | 9.2E-15 | −0.96 | LOC101927636 |
| UBE2Z | rs12453394 | rs318092 | 1381 | 1.2E-14 | −0.93 | UBE2Z |
| HLA-DQA1 | rs9271774 | rs9271770 | 48612 | 6.7E-11 | 1.2 | LOC100996809 |
| OD | ||||||
| SSR1 | rs9505118 | rs3087986 | 1363 | 2.6E-12 | 0.35 | SSR1 |
| UBE2Z | rs12453394 | rs3744608 | 3813 | 4.1E-12 | −0.77 | UBE2Z |
| BRAF | rs9648716 | rs28529157 | 81058 | 2E-08 | −0.45 | BRAF |
| Mahajan et al., 2018 | ||||||
| GWAS gene | rs ID | eQTL SNP | eQTL distance | eQTL FDR | eQTL beta | Probe ID |
| PPP | ||||||
| TTLL6 | rs2032844 | rs11657371 | −145547 | 1.8E-05 | −0.64 | UBE2Z |
| MACF1 | rs2296172 | rs61779279 | 287263 | 0.0010 | −0.2 | MACF1 |
| MLX | rs665268 | rs646123 | −114000 | 0.0014 | 0.24 | CNTNAP1 |
| OD | ||||||
| KIF9 | rs2276853 | rs2276854 | −47481 | 0.0009 | −0.32 | KLHL18 |
| CENTD2 | rs56200889 | rs12575364 | −56695 | 0.0009 | 0.29 | STARD10 |
| TTLL6 | rs2032844 | rs11657371 | −145547 | 0.0014 | −0.41 | UBE2Z |