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. 2019 Mar 14;24:44–63. doi: 10.1016/j.molmet.2019.03.003

Figure 1.

Figure 1

TCF7L2 expression is reduced in white adipose tissue with high-fat diet and genetic models of obesity. (A) Change in body weight of C57Bl/6J mice placed on 10% or 60% HFD for 3 days (males, n = 5, 3-months of age). (B) Tcf7l2 and adipoq (adiponectin) gene expression in eWAT and (C) iWAT. (D) Change in body weight of C57Bl/76J mice placed on 60% HFD for 4 months. (males, n = 5 for each group, 60% HFD started at 14 weeks old) (E) Tcf7l2 and adipoq gene expression in eWAT and (F) in iWAT, gene expression normalized to Rps3 expression.(G) Western blot analysis in iWAT of TCF7L2 and ACTB (β-actin) after 4-month HFD. (H) Tcf7l2 expression in eWAT of control, ob/ob mice and db/db mice, gene expression was normalized to Rps3 expression. (I) Western blot analysis of TCF7L2 and HMGB1 expression in mouse tissues. (J) Tcf7l2 expression in human tissues from publicly available GTEx RNA-Seq data set. (K) Gene expression in fractionated adipose tissue depots from C57BL6/J 3-month old male mice. P-values were determined using Student's t-test, *p < 0.05.