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. 2019 Mar 14;24:44–63. doi: 10.1016/j.molmet.2019.03.003

Figure 5.

Figure 5

Adipocyte specific deletion of TCF7L2 leads to glucose intolerance, insulin resistance and altered adipokine expression on HFD. (A) Glucose tolerance test (GTT) and insulin tolerance test (ITT) of Tcf7l2F/F and Tcf7l2F/F;+Adp-Cre mice on control and HFD for 12 weeks (males n = 9 for contols and n = 11 for Tcf7l2F/F;+Adp-Cre at age 6 months) (B) GTT and ITT for Tcf7l2F/F and Tcf7l2F/F;+Adp-Cre mice on control and HFD for 3 days. (males n = 9 for contols and n = 11 for Tcf7l2F/F;+Adp-Cre at age 3 months) (C) AUC for GTT, fasting insulin, and HOMA IR. (D) gene expression in iWAT and eWAT of adipokines and Glut4, gene expression normalized to Rps3 expression. (males n = 9 for contols and n = 11 for Tcf7l2F/F;+Adp-Cre at age 6 months) P-values were determined using ANOVA o student T-test, *p < 0.05.