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. 2019 Mar 20;24:18–29. doi: 10.1016/j.molmet.2019.03.007

Figure 1.

Figure 1

Lcn2 overexpression in adipose tissue and adaptive thermogenesis in young Lcn2 Tg mice at the age of 16 weeks. Lcn2 protein (A) and gene expression (B–C) levels in brown adipose tissue (BAT) and inguinal white adipose tissue (iWAT) of WT and Lcn2 Tg mice during cold exposure. (D) Body temperature of WT (n = 8) and Lcn2 Tg mice (n = 10) during acute cold exposure. Mice in an ambient temperature of 22 °C serve as controls (n = 9 for Tg and n = 11 for WT mice). (E–F) Thermogenic gene expression in BAT and iWAT during cold exposure, n = 3–5 mice/group. #p < 0.05 or ##p < 0.05 vs 22 °C; *p < 0.05 or **p < 0.01 vs WT of same treatment.