Figure 2:

Changes in viral load and T cell frequencies during CD8 and CD4 depletion studies in SIVmac239 infected, ART-treated rhesus macaques. The initiation of ART in the presence (A) or absence (B) of CD8+ T cells during SIV infection results in similar decay rates of plasma viremia. (C) Viral load increases upon CD8 depletion during short-term ART. (D) Depletion of CD4+ T cells after ART does not result in viral rebound. Key: green arrow represents CD8+ lymphocyte depletion and orange arrow represents CD4+ T cell depletion. Abbreviations: SIV, simian immunodeficiency virus; CD, cluster of differentiation; ART, antiretroviral therapy; P.I., post-infection.