Table 1.
Summary of differential expression of ncRNAs linked to male reproductive disorders.
| Reproductive disorder | Sample | non-coding RNAs | Species | Ref. |
|---|---|---|---|---|
| Azoospermia | Seminal plasma | ↓miR-34c-5p, ↓miR-122, ↓miR-146b-5p, ↓miR-181a, | Human (Homo sapiens) | 101 |
| ↓miR-374b, ↓miR-509-5p, ↓miR-513a-5p | ||||
| Seminal plasma | ↓piR-31068, ↓piR-31925, ↓miR-43771, ↓piR-43773 | Human (Homo sapiens) | 114 | |
| ↓piR-31098 | ||||
| Asthenozoospermia | Seminal plasma | ↑miR-34c-5p, ↑miR-122, ↑miR-146b-5p, ↑miR-181a, | Human (Homo sapiens) | 101 |
| ↑miR-374b, ↑miR-509-5p, ↑miR-513a-5p | ||||
| Sperm | ↑miR-30a, ↑miR-363, ↑miR-26a, ↑miR-200a, ↑miR-141, | Human (Homo sapiens) | 102 | |
| ↑miR-429, ↑miR-193b | ||||
| ↓miR-122, ↓miR-34b, ↓miR-1973 | ||||
| Seminal plasma | ↓piR-31068, ↓piR-31925, ↓miR-43771, ↓piR-43773 | Human (Homo sapiens) | 114 | |
| Sperm | ↓Nrf2, ↓HOTAIR | Human (Homo sapiens) | 115 | |
| DNA damaged sperm | Seminal plasma | ↓miR-424/322 | Human (Homo sapiens) | 104 |
| Erectile dysfunction | Corpus cavernosum tissue | ↓miR-141 | Rat (Rattus norvegicus) | 113 |
| CP/CPPS | Expressed prostatic secretion (EPS) | ↑miR-21-5p, ↑miR-30a-5p, ↑miR-30d-5p, ↑miR103a-3p, | Human (Homo sapiens) | 111 |
| (Chronic prostatitis/Chronic pelvic pain syndrome) | ↑miR-141-3p | |||
| Non-obstructive azoospermia (NOA) | Testicular tissue | ↑miR-193a-3p, ↑miR-193a-5p, ↑miR-210, ↑miR-23a, | Human (Homo sapiens) | 99 |
| ↑miR-302a, ↑miR-371-5p, ↑miR-374a, ↑miR-423-3p, | ||||
| ↑miR-491-3p, ↑miR-554, ↑miR-557, ↑miR-565, | ||||
| ↑miR-572, ↑miR-638, ↑miR-654-5p, ↑miR-663, | ||||
| ↑miR-744, ↑miR-801 | ||||
| Testicular tissue (cryptorchid) | ↓miR-3663-5p, ↓miR-1233-3p, ↓miR-552-5p, ↓miR-449b-5p, | Human (Homo sapiens) | 100 | |
| ↓miR-7153-5p, ↓ miR-122-5p, ↓miR-552-3p, ↓miR-449a | ||||
| Testicular tissue | ↑miR-19b, ↑miR-let-7a | Human (Homo sapiens) | 110 | |
| Oligoasthenozoospermia | Sperm | ↑miR-141, ↑miR-193b, ↑miR-26a, ↑miR-200c, | Human (Homo sapiens) | 102 |
| ↑miR-29a, ↑miR-429, ↑miR-200a | ||||
| ↓miR-34b, ↓miR-15b, ↓miR-34c-5p,↓miR-449b, | ||||
| ↓miR-1973, ↓miR-122, ↓miR-16,↓miR-19a | ||||
| Seminal plasma | ↑miR-1275, ↑miR-4298, ↑miR-3675-3p, ↑miR-765, | Human (Homo sapiens) | 109 | |
| ↑miR-483-5p, ↑miR-1299, ↑miR-766, ↑miR-4306 | ||||
| ↓miR-26b, ↓miR-363, ↓miR-30b,↓miR-17, | ||||
| ↓miR-148a, ↓miR-21, ↓miR-20a,↓miR-23b | ||||
| Sperm | ↓Nrf2, ↓HOTAIR | Human (Homo sapiens) | 115 | |
| Prostate cancer | Blood | ↑miR-1825, ↑miR-484, ↑miR-141, | Human (Homo sapiens) | 112 |
| ↓miR-let-7b, ↓miR-205 | ||||
| SCO (Sertoli cell-only) syndrome | Testicular tissues | ↓miR-202-5p, ↓miR-34c-5p, ↓miR-10b, ↓miR-191, ↓miR-126 | Human (Homo sapiens) | 103 |