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. 2019 May 21;12(7):996–1004. doi: 10.1016/j.tranon.2019.04.011

Table 3.

Prognostic factors for major complications in CRLM patients after surgery in the training set

Factor Univariate analysis
Multivariate analysis
P OR (95%CI) P
Age ≥60 years 0.290
Sex (male vs. female) 0.790
Preoperative CEA ≥10 ng/ml 0.169
Major resection 0.024
Synchronous metastasis 0.278
Primary site colon 0.734
Left hemicolon 0.530
Pretreatment chemotherapy 0.009
R0 resection 0.547
Extrahepatic metastases 0.208
Bilobar distribution 0.574
Diameter of metastases ≥3 cm 0.011
Multiple metastases 0.345
Poorly differentiated 0.652
T3-T4 0.094
Operation time ≥ 301.5 min 0.005
D-dimer ≥0.485 <0.001 3.474 (1.736-6.949) <0.001
GGT ≥35.5 U/L <0.001 2.977 (1.486-5.965) 0.002
Heterochronous resection 0.645



the prognostic value on CPDG score
CPDG = 2 <0.001 Reference -
CPDG = 1 0.112 (0.045-0.276) <0.001
CPDG = 0 0.198 (0.090-0.432) <0.001