Table 4.
Prognostic factors for OS for CRLM patients after surgery in the training set
| Factor | Univariate analysis |
Multivariate analysis |
||
|---|---|---|---|---|
| P | HR (95%CI) | P | HR (95%CI) | |
| Age ≥60 years | 0.764 | 1.064 (0.710-1.594) | ||
| Female | 0.660 | 1.093 (0.735-1.625) | ||
| Preoperative CEA ≥10 ng/ml | 0.109 | 1.374 (0.932-2.028) | ||
| Major resection | 0.001 | 1.957 (1.317-2.910) | ||
| Synchronous metastasis | 0.054 | 1.716 (0.991-2.971) | ||
| Primary site Colon | 0.291 | 1.235 (0.835-1.828) | ||
| Left hemicolon | 0.748 | 1.094 (0.632-1.894) | ||
| Pretreatment chemotherapy | 0.073 | 1.467 (0.964-2.231) | ||
| R0 resection | 0.002 | 0.523 (0.349-0.782) | 0.036 | 0.621 (0.398-0.970) |
| RFA | 0.429 | 1.265 (0.706-2.267) | ||
| Bilobar distribution | <0.001 | 2.157 (1.439-3.232) | 0.025 | 1.672 (1.068-2.620) |
| Extrahepatic metastases | 0.142 | 1.571 (0.859-2.872) | ||
| Diameter of metastases ≥3 cm | 0.232 | 1.268 (0.859-1.871) | ||
| Multiple metastases | 0.003 | 1.882 (1.248-2.837) | ||
| Poorly differentiated | 0.932 | 1.022 (0.626-1.667) | ||
| T3-T4 | 0.363 | 1.292 (0.744-2.242) | ||
| Operation time ≥ 301.5 min | 0.026 | 1.565 (1.055-2.324) | ||
| D-dimer ≥0.285 mg/L | 0.005 | 1.817 (1.193-2.769) | 0.011 | 1.751 (1.139-2.691) |
| GGT ≥30.5 U/L | 0.004 | 1.786 (1.199-2.611) | ||
| Heterochronous resection | 0.961 | 0.990 (0.666-1.472) | ||
| The prognostic value on CPDG score | ||||
| CPDG = 2 | - | Reference | - | Reference |
| CPDG = 1 | <0.001 | 0.334 (0.187-0.597) | 0.002 | 0.390 (0.214-0.710) |
| CPDG = 0 | 0.014 | 0.198 (0.374-0.894) | 0.132 | 0.704 (0.446-1.112) |