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. 2019 May 22;4(3):e00047-19. doi: 10.1128/mSphere.00047-19

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Copyright © 2019 Besson et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 7 — Inhibition of RABV infection by Ro-31-8220 mesylate and PD 198306 in human neurons. Human iPSCs were infected with Tha-Crimson at an MOI of 3 after 6 h of treatment with DMSO (0.5%), PD 198306, Ro-31-8220 mesylate, or wortmannin. Cells were fixed with 4% PFA at 36 h postinfection. Images were acquired (A) and analyzed (B) to determine the relative numbers of nuclei (Nucleus intensity) and the relative quantities of Tha-Crimson (E2-Crimson intensity). The data corresponding to the latter were fitted using nonlinear regression. Each value represents the mean of data from 2 separate wells, and error bars represent standard deviations. Data corresponding to differences between the results seen with the compounds and the results seen with DMSO were assessed using ANOVA in Prism 7 (GraphPad). The P values and images are annotated for the lowest dose with a significant effect. ***, P < 0.001; **, P < 0.01; *, P < 0.05. Dotted line = average Tha-Crimson value in DMSO.