FIG. 10.

Loss of MMP9 does not affect CD44 expression after mFPI. Post-injury analysis of OB CD44 showed significant elevation at both 3 and 7 days in the MMP9 KO, similar to the profile observed in WT injured cases (replotted from Fig. 5). No strain differences were detected in post-hoc analysis. Similarly, injury did not change CD44 protein at either 1 or 21 days in the KO. Results are expressed as percent of sham control ROD (100% dashed line). Representative CD44 blot images, with cyclophilin A and β-actin load controls, illustrated below. *p < 0.05, ***p < 0.001 vs. sham; n = 3–5/group. KO, knockout; mFPI, mild fluid percussion injury; MMP, matrix metalloproteinase; OB, olfactory bulb; ROD, relative optical density; WT, wild type.