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. 2019 May 6;36(10):1615–1631. doi: 10.1089/neu.2018.5994

FIG. 7.

FIG. 7.

MMP9 KO alters cellular expression of OPN after mFPI. (A) Imaging of sham, WT FPI, and MMP9KO FPI cases at 3 days post-injury shows reduction of OPN labeling in presumptive tufted and mitral neurons of the KO (white arrows) when compared to 3-day WT FPI. (B) Strong WT OPN induction at 7 days after FPI relative to sham is also clearly attenuated in the post-injury MMP9 KO. This result is consistent with significant WB loss of 48-kD OPN in the MMP9 KO. Bar = 50 μm; n = 3–4/group. EPL, external plexiform layer; GL, glomerular layer; KO, knockout; MCL, mitral cell layer; mFPI, mild fluid percussion injury; MMP, matrix metalloproteinase; OPN, osteopontin; WB, western blot; WT, wild type.