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. 2019 May 15;10:580. doi: 10.3389/fphys.2019.00580

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Copyright © 2019 Lopez-Perez, Sebastian, Izquierdo, Ruiz, Bishop and Ferrero.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison between real and simulated ECG signals recorded at precordial leads in sinus rhythm. These plots display the ECG simulated with all model versions including ER (models #5–8), combined with the four tested levels of image-based patchy fibrosis in the BZ. The ECG for the model version with ER, 10% fibrosis and the CVs reduced by 50% in BZ (10% fib*), instead of 75%, is also represented. Correlation coefficients (CORR) are included in the plots legend. Those signals were obtained by propagating through the 3D torso model the sixth heartbeat simulated from the CARTO-derived sinus activation pattern at a BCL of 800 ms (75 bpm). (see Supplementary Material for simulated ECGs with model versions without ER in the BZ).