Table 2.
Subgroup | Genetic model | Effects model |
Test of heterogeneity | Test of association | ||
I2 | P | OR | 95% CI | |||
−607C>A | ||||||
Overall | AA vs CC | Random | 70.2% | 0.01 | 1.27 | 0.82–1.96 |
CA vs CC | Fixed | 39.7% | 0.16 | 1.06 | 0.89–1.26 | |
Dominant model | Random | 59.8% | 0.04 | 1.09 | 0.83–1.43 | |
Recessive model | Random | 52.5% | 0.08 | 1.23 | 0.92–1.65 | |
Consistent with | AA vs CC | Fixed | 0.00% | 0.80 | 1.01 | 0.77–1.31 |
HWE | CA vs CC | Fixed | 0.00% | 0.72 | 0.94 | 0.77–1.15 |
Dominant model | Fixed | 0.00% | 0.72 | 0.96 | 0.79–1.16 | |
Recessive model | Fixed | 0.00% | 0.80 | 1.04 | 0.83–1.31 | |
−137G>C | ||||||
GG vs CC | Fixed | 2.00% | 0.36 | 1.42 | 0.78–2.58 | |
GC vs CC | Fixed | 0.00% | 0.38 | 1.16 | 0.62–2.16 | |
Dominant model | Fixed | 0.00% | 0.38 | 1.34 | 0.74–2.43 | |
Recessive model | Random | 78.4% | 0.03 | 0.96 | 0.26–3.56 |