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. 2019 May 16;10:1108. doi: 10.3389/fimmu.2019.01108

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Copyright © 2019 Son, Shim, Hwang, Park and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Paclitaxel mediates JNK signaling-dependent priming of NLRP3 inflammasome activation. (A) Immunoblots of cellular lysates from mouse BMDMs untreated (Unt) or treated with paclitaxel (5 μM) or LPS (0.25 μg/mL) for 15, 30, or 60 min. (B) Immunoblots of cellular lysates from mouse BMDMs treated with paclitaxel (5 μM) or LPS (0.5 μg/mL) for 3 h. (C) Immunoblots of cultural supernatants or cellular lysates from mouse BMDMs treated with paclitaxel (5 μM, 3 h) or LPS (0.25 μg/mL, 3 h) after pretreatment with SP600125 (20 μM, 30 min). (D) Immunoblots of cultural supernatants or cellular lysates from mouse BMDMs treated with paclitaxel (5 μM, 3 h) or LPS (0.25 μg/mL, 3 h) after pretreatment with SP600125 (20 μM, 30 min), followed by treatment with ATP (2.5 mM, 30 min).