Table 2.
Associations (odds ratios, OR) for adjusted percent density (PD) and dense area (DA) measures with breast cancer risk, with or without polygenic risk score (PRS). All eight studies and restricted to cohort/population-based studies only
| Adjusted density measure* | Full sample | Cohort/population-based studies only | ||||
|---|---|---|---|---|---|---|
| N case/N control | OR (95% CI) | Adj for PRS OR (95% CI) |
N case/N control | OR (95% CI) | Adj for PRS OR (95% CI) |
|
| PD (per 1 SD) | 3628/5126 | 1.45 (1.38, 1.52) | 1.42 (1.36, 1.50) | 2439/3895 | 1.42 (1.34, 1.50) | 1.40 (1.32, 1.48) |
| PD quartiles | ||||||
| 1 | 531/1282 | 0.60 (0.52, 0.70) | 0.61 (0.52, 0.70) | 450/1064 | 0.61 (0.51, 0.72) | 0.62 (0.52, 0.73) |
| 2 (Ref) | 723/1281 | Ref | Ref | 519/984 | Ref | Ref |
| 3 | 946/1282 | 1.25 (1.09, 1.42) | 1.22 (1.06, 1.39) | 615/939 | 1.20 (1.03, 1.41) | 1.18 (1.00, 1.38) |
| 4 | 1428/1281 | 1.64 (1.44, 1.87) | 1.60 (1.40, 1.82) | 855/908 | 1.51 (1.29, 1.76) | 1.48 (1.27, 1.74) |
| DA (per 1 SD) | 3628/5126 | 1.34 (1.28, 1.41) | 1.32 (1.26, 1.39) | 2439/3895 | 1.36 (1.29, 1.44) | 1.35 (1.28, 1.44) |
| DA quartiles | ||||||
| 1 | 530/1283 | 0.56 (0.49, 0.65) | 0.57 (0.50, 0.66) | 427/1040 | 0.58 (0.40, 0.69) | 0.59 (0.50, 0.70) |
| 2 (Ref) | 764/1281 | Ref | Ref | 535/1003 | Ref | Ref |
| 3 | 964/1281 | 1.15 (1.01, 1.31) | 1.15 (1.00, 1.31) | 644/969 | 1.14 (0.98, 1.33) | 1.13 (0.97, 1.33) |
| 4 | 1370/1281 | 1.41 (1.23, 1.61) | 1.38 (1.21, 1.59) | 833/883 | 1.45 (1.24, 1.69) | 1.44 (1.22, 1.69) |
*Residuals from models adjusted for age, 1/BMI, and study
Heterogeneity of density association across population-based studies: PD phet = 0.08; DA phet = 0.04 (Exclusion of MMHS results in PD phet = 0.42; DA phet = 0.25)
SD standard deviation, CI confidence interval, Ref reference group, Adj adjusted